AKT1 and in situ carcinoma: Using bioinformatics analysis in combination with pharmacological inhibition or shRNA-mediated knockdown, and subsequent cell viability assay, we systematically revealed that Aurora-A enhanced PTX and CIS chemosensitivity by up-regulation of the AKT/mTOR signaling pathway in EC Ishikawa and HEC-1B cell lines Accordingly, a synergetic relationship between Aurora-A expression and AKT/mTOR signaling was also clearly observed in EC tissues.