The most frequently mutated genes were TP53, APC, and KRAS. Wild type TP53 was associated with a good response to nCRT (Risk Ratio = 1.30, 95% CI = 1.14–1.49, P < 0.001) in a meta-analysis with 1,830 rectal cancer patients from 30 studies (43). This evidence concerns the gene APC and rectal cancer.