Eltrombopag is a small molecular weight, non-peptide, oral TPO-R agonist that binds with the transmembrane domain of a TPO receptor and induces the Janus Kinase/Signal transducer and activator of transcription pathway, thus stimulating megakaryocytopoiesis with a significant increase in platelet production in patients suffering from ITP [30]. Here, MPL is linked to autoimmune thrombocytopenic purpura.