HIF1A and myocardial infarction: As shown in Figure 5, HIF-1 (hypoxia-inducible factor-1) expressions in the sham group were much less than those in MI control and drug groups, indicating no infarction happened leading to lack of HIF gene expression; expressions of HIF in FD1000 and Betaloc groups were higher than those in the MI control group, but the differences were not significant (p > 0.05), indicating that PN-F might induce production of HIF and VEGFA genes but not obviously.