NF2 and neoplasm: Figure 2 depicts a representative patient with a large primary tumor harboring an NF2 driver mutation with vasogenic edema prior to initial resection compared with the patient’s recurrent tumor also presenting with substantial vasogenic edema. Moreover, presence of an NF2 mutation was found to be an independent predictor of mitotic index on multivariate regression analysis (beta=3.0, p = 0.006, Table 2). Mean mitotic index for NF2 mutation positive tumors was 4.7 per 10 HPF (SD = 5.4) compared to 1.5 (SD=2.3) without the mutation (p = 0.014).