Taken together, in this study, the acquisition of 5FU and Dox chemoresistance in DP-HCC1806:BMMSCs is likely due to a CAM-DR mechanism, in which CD9, IL6, and CCL5/CCR5 collectively mediate tumor-growth, adhesion and anti-apoptotic signals, via integrin-dependent mechanisms. Here, IL6 is linked to neoplasm.