PARK7 and Parkinson disease: A key example includes DJ-1/PARK7, a molecular chaperone known to regulate Keap1-Nrf2 signaling, which is the primary sensor for reactive electrophiles activating Nrf2 nuclear translocation and transactivation of the antioxidant response element (ARE) in a battery of cytoprotective genes facilitating protection from oxidative stress pathogenesis [7] including experimental models of PD [8].