Here, we hypothesized that MCE and scopoletin prevent rotenone-induced oxidative stress and apoptosis through the activation of DJ-1/Nrf2 signaling and investigated its neuroprotective effects using in vivo (Sprague-Dawley rats) and in vitro (SH-SY5Y cells) models of PD. This evidence concerns the gene NFE2L2 and Parkinson disease.