On the other hand, a study set up in the emergency department by Wang et al. [46] suggested that combined NGAL and TIMP-1 (tissue inhibitor of matrix metalloproteinases-1, a cell cycle arrest biomarker for AKI) was useful for the diagnosis and risk stratification of patients with AKI, including those who also presented with sepsis. This evidence concerns the gene LCN2 and acute kidney injury.