Plasma OPG levels were significantly associated with stroke, MESs, and stroke severity at admission (adjusted OR [95% CI]: 1.002 [1.001–1.003] p < 0.001; 1.002 [1.001–1.003] p = 0.001; 1.001 [1.000–1.002] p = 0.028). This evidence concerns the gene TNFRSF11B and stroke disorder.