In the COADREAD expression dataset, NFE2L3 was markedly upregulated in colorectal cancer samples compared with normal samples (Figure 1(c), p < 0.0001), validated by our real-time PCR assay in 48 paired paratumor and tumor samples (Figure 1(d), p < 0.0001). Here, NFE2L3 is linked to colorectal cancer.