In another report, they generated HSPCs from iPSC-derived HE using a combination of seven transcription factors, ERG, HOXA5, HOXA9, HOXA10, LCOR, RUNX1, and SPI1. These factors supported multilineage/long-term engraftment and reconstitution of HE undergoing endothelial-to-mesenchymal transition (EHT) upon transplantation into primary and secondary sublethally irradiated NSG mice [130]. The gene discussed is SPI1; the disease is hereditary elliptocytosis.