It reported that STAT2 and JAK/STAT pathway (osteoclast differentiation pathway) were closely associated with cartilage relevant diseases, such as osteoarthritis (OA) cartilage or in human articular chondrocyte mechanotransduction [47], the bovine intervertebral disc [48], and rheumatoid arthritis (RA) [49]. This evidence concerns the gene STAT2 and osteoarthritis.