ANTXR1 and neoplasm: Finally, the facts that LeTx binds to ANTXR1, LeTx can reduce tumor growth in vivo, and ANTXR1 is expressed/enriched on the surface of CSCs suggest that the antitumor effects observed with LeTx in the studies published by Duesbery et al. [21] and Rouleau et al. [23] were likely a consequence of CSC targeting.