IL6 and cancer: This binding leads to the activation of the canonical IL-6-activated Janus Kinase- (JAK-) Signal Transducers and Activators of Transcription (STAT) pathway and Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) signaling, two of the most deregulated pathways involved in different stages of cancer development and progression [11].