IL-8 is a proinflammatory CXC ELR+ chemokine, identified for its role as “neutrophil chemotactic factor”: indeed, IL-8 mainly acts as a promoter of chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection, where it promotes their chemotaxis and degranulation [41]. The gene discussed is CXCL8; the disease is infection.