Treatment with TrkB-Fc was shown to dampen the stroke-induced effect, with TrkB-Fc-treated stroke animals performing similarly to aged sham animals across all variables (consecutive days, p = 0.8495; total trials, p = 0.5158; total correction trials, p = 0.5119; and total ITI touches, p = 0.8860). Here, NTRK2 is linked to Stroke.