Corresponding results in clinical studies suggested a critical effect of TCF4 in several phenotypes of schizophrenia, including age at onset, sensorimotor gating, negative symptoms, cognitive function and MRI-measured brain structure (Albanna et al., 2014; Hui et al., 2015; Chow et al., 2016; Alizadeh et al., 2017). Here, TCF4 is linked to schizophrenia.