Inversion events leading to human diseases are not limited to F8 gene, other genes, such as IDS gene (Hunter syndrome), MSH2 gene (Lynch syndrome), EML4-ALK rearrangement in non-small cell lung cancer (NSCLC), AP3B1 (Hermansky-Pudlak syndrome type 2), have been previously implicated (Bondeson et al., 1995; Soda et al., 2007; Jones et al., 2013; Rhees et al., 2014). This evidence concerns the gene IDS and non-small cell lung carcinoma.