ACTA1 and Diffuse mesangial sclerosis: IL-1β blockade did not significantly affect interstitial fibrosis as detected by aSMA staining or mesangial sclerosis as detected by Sirius red staining (Supplementary Figures 1B-E), though anti-IL-1β treatment reduced αSMA but not collagen 1alpha1 gene expression (Supplementary Figures 2J,K).