Such subset has been already associated with autoantibody production in other models of autoimmune diseases (11) and our observation suggest that perhaps, in ALPS-FAS the dysregulated differentiation of this specific subset of cTfh resulted in selection of autoreactive B cells and consequent autoantibody production as suggested in rheumatoid arthritis and SLE (11). This evidence concerns the gene FAS and systemic lupus erythematosus.