The absolute counts reflected the changes observed in the proportion of the T cell subsets of ALPS-FAS patients with or without CD4 T-cells lymphopenia: CD4 [median 257 (IQR: 216–294) vs. 774 (IQR: 624–946) cells/μL, p < 0.0001], CD8 [median 290 (IQR: 203–450) vs. 459 (IQR: 301–796) cells/μL, p = 0.046], DNT [median 119 (IQR: 67–268) vs. 216 (IQR: 83–358) cells/μL, p = 0.25] (Figure 3D). This evidence concerns the gene CD8A and lymphopenia.