However, the proteasome-mediated STAT1 degradation was rapid and could be observed in the first several hours after viral infections (~4–10 h p.i.)(58, 59), while SFTSV infection resulted in STAT1 abundance decrease with rather different kinetics (Figure 7A) and the protein reduction was noticed at 24–48 h p.i. and later, indicating that the other cellular processes such as the lysosomal degradation pathways may be involved. Here, STAT1 is linked to viral infectious disease.