In line with Pfirschke's work, we recently showed that 5-Fluorouracil plus Oxaliplatin (Folfox), in contrast to monotherapies, drove complete tumor cures in two mouse colorectal cancer models when combined to anti-PD-1 treatment, thereby suggesting that Folfox administration renders colorectal tumors sensitive to PD-1 blockade (75). This evidence concerns the gene PDCD1 and neoplasm.