Interestingly, higher tumor PD-L1 expression (≥50%) was associated with an enhanced response rate of 80% but given the relatively low numbers of patients studied and observations that patients with <1% PD-L1 expression and with ≥1% PD-L1 expression featured comparable response rate of 54 and 57%, respectively, this study did not conclude on any link between combined treatment efficacy and tumor PD-L1 expression (116). The gene discussed is CD274; the disease is neoplasm.