In particular, insulin resistance development depends on CD8+ effector T cells as follows: CD8+ T cell infiltration into adipose tissues precedes the accumulation of macrophages; genetic depletion of CD8+ T cells decreases adipose tissue inflammation and ameliorates systemic insulin resistance; and adoptive transfer of CD8+ T cells to CD8-deficient mice aggravates adipose inflammation (71). This evidence concerns the gene CD8A and Insulin resistance.