In the early stage of sepsis in these patients, pro-inflammatory cytokines such as TNFα, IL-1, GM-CSF, and IL-6, drove the deactivation of monocytes by down regulating HLA-DR through IL-10 and TGF-β mediated pathways and diminished capacity for pro-inflammatory cytokine production (16, 18). This evidence concerns the gene CSF2 and Sepsis.