The similarities of symptoms in human MRTF-A deficiency and β2-integrin deficiency, together with the results presented here, indicate that some of the functions of integrins and kindlin-3 in immune cells, which are impaired in LAD patients may involve regulation of transcription through the MRTF-A/SRF pathway. The gene discussed is SRF; the disease is hyperinsulinemic hypoglycemia, familial, 4.