Subjects with previous vasculitic manifestations had higher PTX3 levels than those without (2.3 ng/ml, IQR = 1.26–4.83, n = 220 vs. 1.43 ng/ml, IQR = 0.88–2.81, n = 146; p < 0.001) and patients with active vasculitis had higher levels of PTX3 compared to patients without evidence of vasculitis at time of sampling (3.15 ng/ml, IQR = 1.31–7.75, n = 85 vs. 1.72 ng/ml, IQR = 1.08–3.37, n = 278; p < 0.001 Figure 4D). Here, PTX3 is linked to vasculitis.