PTX3 levels were significantly higher in patients with systemic inflammatory immune-mediated and autoimmune diseases (2.33 ng/ml, IQR: 1.26–4.89, n = 287) than in HCs (1.22 ng/ml, IQR:0.80–1.98, n = 79; p < 0.001). This evidence concerns the gene PTX3 and autoimmune disease.