NOTCH1 and metabolic syndrome: Strategies aimed to prevent a reduction of Notch1 caused by turbulent shear stress (31) or dyslipidemia (25) or low estrogen conditions, as in post-menopausal women or breast cancer patients treated with anti-estrogens (152) could reduce endothelial dysfunction and therefore, plaque formation in atheroprone areas of the aortic endothelium.