MADCAM1 and type 1 diabetes mellitus: Collectively, these results suggest that by inhibiting the interaction between α4β7 on T or B lymphocytes from NOD mice, and MADCAM-1 on endothelial cells, AS101 and SAS might affect attachment and penetration of autoreactive T and B cells through pancreatic high endothelial venules, potentially affecting the course of T1D.