The novel amyloid precursor protein APP p.D678H mutation (NM 000484.3 APP c.2032G > C) has been reported in two families with autosomal dominant Alzheimer's disease (AD) characterized by an early onset of memory impairment and progress to dementia, and a tendency to develop cerebral amyloid microangiopathy (1–3). This evidence concerns the gene APP and memory impairment.