The protective effect of D-PUFAs against ROS has been demonstrated in yeast (Hill et al., 2011; Cotticelli et al., 2013; Andreyev et al., 2015), in primary co-cultures of neurons and astrocytes (Angelova et al., 2015) as well as in AD mouse model Aldh2-/- (Elharram et al., 2017) by supplementing the media with deuterated LA or ALA (Figure 1C; Hill et al., 2011; Cotticelli et al., 2013; Andreyev et al., 2015). This evidence concerns the gene ALDH2 and Alzheimer disease.