TTN and atrial fibrillation: Furthermore, human studies have identified that alterations of 10 novel genetic loci, including METTL11B/KIFAP3, ANXA4/GMCL1, CEP68, TTN/TTN-AS1, KCNN2, KLHL3/WNT8A/FAM13B, SLC35F1/PLN, ASAH1/PCM1, SH3PXD2A, and KCNJ5, are associated with AF susceptibility (Christophersen et al., 2017).