Moreover, we found that 87 pathways were significantly changed in Ang II-infused atrial tissues (P < 0.05), including lysosomal and phagosomal pathways and those involved in Staphylococcus aureus infection, antigen processing and presentation, viral myocarditis, chemokine and PI3K-AKT signaling, extracellular matrix (ECM)-receptor interaction, and focal adhesion (Figure 3C). This evidence concerns the gene PIK3CA and viral myocarditis.