Clinically, in T2D patients that frequently fail to respond to antiplatelet therapy (Samos et al., 2016), the alteration of the MT1P3 epigenetic pathway seems associated with risk of microcirculation complications and thrombotic microangiopathies higher than in the non-diabetic population (Ding et al., 2017). Here, MT1P3 is linked to type 2 diabetes mellitus.