Specifically, in patients with MI, it has been found a significant presence of ANRIL genomic locus variants such as rs10757278 (Helgadottir et al., 2007), rs10965215 and rs10738605 (Cheng et al., 2017), highlighting the concept that MI predisposition might be associated with the genetic variation of an epigenetic non-coding modulator. Here, CDKN2B-AS1 is linked to myocardial infarction.