CEBPB and cancer: Other studies have found that the activation of C/EBPβ is crucial for the initial induction of COX-2 by growth factors, tumor promoters, cytokines, and other inflammatory mediators in various cell types (Thomas et al., 2000; Wu et al., 2005), supporting the idea that suppression of this pathway, as demonstrated by SSd, may be an important anti-cancer therapy.