Among the most validated factors, the Patatin-like phospholipase-3 (PNPLA3)/adiponutrin, rs738409 C > G SNP, I148M (Valenti et al., 2010) variant is involved both in hepatic lipid remodeling and in lipoprotein secretion, determining a greater predisposition to NASH (He et al., 2010; Ruhanen et al., 2014). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.