A study by Wei implied that the downregulation of TRIB3 attenuated endoplasmic reticulum stress, enhanced Akt phosphorylation, and protected neuron from apoptosis by stereotaxic injection of TRB3 shRNA lentivirus in the global cerebral ischemia and reperfusion injury in rats (Wei et al., 2017). Here, TRIB3 is linked to brain ischemia.