To further investigate the mechanism of how BC032585 lncRNA modulates the sensitivity of tumor cells to TA treatment, we examined MDR1 protein expression in MDA-MB-231 cells following BC032585 knockdown as both DOX an PTX are substrates of MDR1, and MDR1 is known to confer resistance to a variety of anticancer agents including doxorubicin and paclitaxel (Abraham et al., 2010; Chen et al., 2016). The gene discussed is ABCB1; the disease is neoplasm.