Thus, the IL233 hybrid cytokine, which contains the activities of IL-2 and IL-33, promotes Tregs systemically, inhibits inflammation, restores glucose homeostasis, promotes recruitment of ILC2, eosinophils, and AAM in the adipose tissue to attenuate obesity, offers multi-level protection from obesity linked diabetic nephropathy. This evidence concerns the gene IL33 and obesity due to melanocortin 4 receptor deficiency.