NF-κB can regulate cytokines, cell adhesion molecules, inflammatory factors and other inflammation-related factors [such as monocyte chemotactic protein 1 (MCP-1), IL-6, IL-8, IL-18, and TNF-α] in DN once it is activated (Mudaliar et al., 2014; Ma et al., 2015). The gene discussed is CCL2; the disease is liver dysplastic nodule.