CCL2 and atherosclerosis: Interestingly, deletion of both CCL2 and CX3CR1, or CCR2 and CX3CL1 even further decreased atherosclerosis development compared with single deficiencies in the proteins, which could be attributed to a strongly attenuated monocytosis and hence reduced plaque macrophage accumulation (Combadiere et al., 2008; Saederup et al., 2008).