There is another natural product, Dioscin is also can rescue intrahepatic cholestasis in ANIT-Induced rat model through regulating transporters, apoptosis, and oxidative stress (Yao et al., 2017) and through regulating Oatps, Mrp2, and Bsep expression (Zhang et al., 2016). This evidence concerns the gene ABCB11 and intrahepatic cholestasis.