NTN1 and Alzheimer disease: In animal models of AD, netrin-1 has been reported to reduce Aβ1–40-induced Aβ1–42 increases, as demonstrated in vitro, and decrease both Aβ1–40 and Aβ1–42 in PDAPPSwe/Ind transgenic mice, effects which were accompanied with improved working memory (Spilman et al., 2016).