One of the mechanisms involved in the progression of tauopathies is inter-cellular and trans-regional propagation of the altered protein tau (de Calignon et al., 2012; Liu et al., 2012; Iba et al., 2013; Dujardin et al., 2014; Peeraer et al., 2015; Stancu et al., 2015; Lewis and Dickson, 2016; Goedert and Spillantini, 2017; Mudher et al., 2017). Here, MAPT is linked to tauopathy.