MAPT and tauopathy: The present findings are in line with previous observations concerning tau seeding and spreading of abnormal tau derived from human brain homogenates of different tauopathies inoculated into the brain of mice (Clavaguera et al., 2009, 2013a,b, 2015; Ahmed et al., 2014; Boluda et al., 2015; Audouard et al., 2016; Guo et al., 2016; Narasimhan et al., 2017; Ferrer et al., 2018).