Two mice unilaterally injected in the hippocampus with sarkosyl-insoluble fractions of AD at the age of 10 months and killed at the age of 16 months showed tau deposition in neurons and rare glial cells of the hippocampus (dentate gyrus and CA1 region), in glial cells in the fimbria (Figures 2A–C), and in some fibers and neurons in septal nuclei and periventricular hypothalamus (data not shown). This evidence concerns the gene MAPT and Alzheimer disease.