Similarly, double-labeling immunofluorescence with anti-phospho-tauThr181 and phospho-ERK 1/2 (Thr202/Tyr204) showed co-localization of tau and phospho-ERK 1/2-P in oligodendrocytes in the corpus callosum of mice inoculated with sarkosyl-insoluble fractions from tauopathies (Figure 7D). This evidence concerns the gene MAPT and tauopathy.