NT5E and myeloid sarcoma: Further in vivo studies will be required to test the relative importance of this mechanism of astrocyte-mediated control of the reactivity of infiltrating T cells in comparison with the role of the enriched synaptic CD73 (Cunha et al., 2000) controlling the activity of glutamatergic synapses (Cunha et al., 1996; Rebola et al., 2008), that has also been proposed to contribute for MS (Peterson et al., 2001; Wegner et al., 2006; Dutta et al., 2011).