ADNP and Cognitive impairment: Interestingly, administration of the peptide sequence NAP (NAPVSIPQ), derived from ADNP, inhibited apoptosis (Leker et al., 2002; Gozes and Divinski, 2007), enhanced ADNP-LC3-II interaction (Merenlender-Wagner et al., 2014), reversed the decrease in hippocampal Beclin1 mRNA levels in a mouse model of schizophrenia (MAP6-deficiency) and decreased cognitive deficits and tau hyperphosphorylation in ADNP+/−mice (Vulih-Shultzman et al., 2007).