Interestingly, at 28 d.p.i, when new born GCs are fully mature, the number of dendritic spines in GC lacking FMRP was no different to control GCs (Scotto-Lomassese et al., 2011), suggesting that neurons without FMRP exhibited an accelerated rate of spinogenesis, that could homeostatically counterbalanced during development in an attempt to re-establish similar rates of connectivity in the FXS network. This evidence concerns the gene FMR1 and fragile X syndrome.