In addition, LGR5 was found to be overexpressed in high grade NB (Forgham et al., 2015; Vieira et al., 2017), working upstream of the MEK/ERK and Akt pro-survival signaling pathways (Vieira et al., 2017) which are often triggered in primary NB tumors (Opel et al., 2007). Here, LGR5 is linked to neuroblastoma.