Yet another natural inhibitor of STAT3 called curcumin or turmeric (diferuloylmethane), also known as an inhibitor of Akt, COX2 and NF-κB signaling, demonstrated anti-cancer properties which rendered it a chemo-sensitizing agent against various tumors including glioma, NB, cervical carcinoma, epidermal carcinoma, prostate cancer, and colon cancer (Goel and Aggarwal, 2010). This evidence concerns the gene AKT1 and neuroblastoma.