L1 cell adhesion molecule known as L1-CAM, is a well-established CSC marker in various tumors including gliomas (Bao et al., 2008) and NB (Rached et al., 2016) and has been shown to confer chemo- and radio-resistance (Held-Feindt et al., 2012; Rached et al., 2016) in these aggressive cancers. The gene discussed is L1CAM; the disease is neuroblastoma.