SNCA and Parkinson disease: Parkinson’s Disease (PD), a multifactorial neurodegenerative disorder that affects the motor, cognitive and peripheral system, is characterized by the accumulation of misfolded, aggregated alpha-synuclein (αS) fibrils into proteinaceous intracellular inclusions in neuronal soma or neurites, named Lewy bodies (LB) or Lewy neurites (LN) (Goedert et al., 2013).