ACHE and early-onset autosomal dominant Alzheimer disease: Physostigmine, the first AChE inhibitor known to man, is a carbamate readily passing the blood–brain barrier that has been used in the therapy of atropine poisoning, myasthenia gravis, Alzheimer’s disease, and glaucoma (for review, see Somani and Dube, 1989; Zhao et al., 2004).