On Cox regression analysis, Lg(IL-6) (relative risk (HR) 1.252; 95% confidence interval (CI) 1.059–1.481), Lg(APN) (HR 0.075; 95% CI 0.588–0.845), DBP (HR 1.011; 95% CI 1.002–1.019), and dyslipidemia (HR 1.485; 95% CI 1.090–2.024) were independent risk factors for CVD patients in the Kazakh population. Here, IL6 is linked to metabolic syndrome.