Tokuda et al27 found that SCUBE1 had an inhibitory effect on tumor development to some extent.28 Our results show that SCUBE1 expression in miR‐22 overexpression samples is higher than in the control, indicating that the inhibitory effect of miR‐22 on tumor metastasis may be related to the upregulation of SCUBE1 expression. Here, SCUBE1 is linked to neoplasm.