However, CD4+ iNKT cell percentage was correlated with total peripheral blood CD4 T-cell count (r = 0.456, P = .001; Figure 2C) and there was an inverse correlation with HIV-1 viral load (r = –0.571, P < .001; Figure 2D), indicating that most severe depletion of CD4+ iNKT cells occurred in advanced HIV infection. The gene discussed is CD4; the disease is HIV infectious disease.