Multivariable modeling including data from timepoints ARV0, ARV2, and ARV4 demonstrated a significant association between TB-IRIS and increased iNKT cell frequency, adjusted for age and sex (P = .022; Supplementary Table 3) but no increase in iNKT cell frequency over time, and the association did not differ with total peripheral blood CD4 T-cell count, nor HIV viral load. Here, CD4 is linked to tuberculosis.